Journal article
Analysis of Rates of Completion, Delays, and Participant Recruitment in Randomized Clinical Trials in Surgery
Cade Shadbolt, Elise Naufal, Samantha Bunzli, Veronique Price, Siddharth Rele, Chris Schilling, Sharmala Thuraisingam, L Stefan Lohmander, Zsolt J Balogh, Philip Clarke, Peter Choong, Michelle Dowsey
JAMA Network Open | JAMA Network | Published : 2023
Abstract
IMPORTANCE: Discontinuation and nonpublication are established sources of avoidable waste among surgical trials, but rates of delayed completion and recruiting shortfalls remain unclear. OBJECTIVES: To examine the rate of delayed completion, incomplete enrollment, and discontinuation among randomized clinical trials in surgical populations and the duration of delays and extent of recruiting shortfalls among these trials. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study examined randomized clinical trials in surgical populations registered on ClinicalTrials.gov between January 1, 2010, and December 31, 2014. Analysis was conducted between October 27, 2021, and June 30, 2022. MAIN..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by grant APP1122983 from the National Health and Medical Research Council (Drs Dowsey, Choong, and Bunzli).